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GENFIT Reports Full-Year 2023 Financial Results and Provides Corporate Update | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
By: GlobeNewswire - 04 Apr 2024 | Back to overview list |
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Lille, France; Cambridge, MA; Zurich, Switzerland; April 4, 2024 - GENFIT (Nasdaq and Euronext: GNFT), a late-stage biopharmaceutical company dedicated to improving the lives of patients with rare and life-threatening liver diseases, today announced annual financial results for the year ended December 31, 2023. A summary of the consolidated financial statements is included below. Pascal Prigent, CEO of GENFIT commented: “A remarkable milestone was reached by GENFIT in 2023 with the announcement of positive topline data for our Phase 3 ELATIVE® trial evaluating elafibranor in Primary Biliary Cholangitis. We are now fast approaching the PDUFA1 action date for elafibranor and this means that, in 2024, GENFIT could reach another key milestone with the first molecule developed in-house being made available to patients. Approval and commercialization would mean that we would receive additional milestones and a regular stream of royalty payments, which will be used to finance our pipeline now mainly focused on Acute-on-Chronic Liver Failure. Looking ahead in 2024, GENFIT will continue to strengthen its leadership in ACLF and intensify collaboration with leading academic institutions and research foundations such as EF CLIF. We are confident that our success in PBC can be replicated in this therapeutic area where the unmet medical need is huge.”
Primary Biliary Cholangitis (PBC): positive results for Phase 3 ELATIVE® trial followed by the validation of the Marketing Authorization Application (MAA) for elafibranor by the FDA, EMA and UK MHRA, and publication in the New England Journal of Medicine In June 2023, GENFIT and Ipsen announced positive 52-week topline data from the pivotal ELATIVE® Phase 3 trial evaluating elafibranor in PBC. In the trial, significant treatment benefit was achieved with elafibranor, with a high responder rate, and a low placebo effect on the primary composite endpoint (a 47% placebo-adjusted difference (p<0.0001) between patients on elafibranor 80mg (51%) compared with patients on placebo (4%) achieving a biochemical response). The key secondary endpoint on serum alkaline phosphatase (ALP) normalization was achieved – despite a high baseline ALP level – with high statistical significance. On the other key secondary endpoint using the PBC Worst Itch NRS score, the reduction of pruritus observed for elafibranor versus placebo was not statistically significant. Two other secondary patient-reported outcome measures were used to assess itch, and greater reductions in pruritus were observed with elafibranor compared with placebo at Week 52, according to the itch domain of PBC-40 quality of life questionnaire and 5-D Itch total score. Elafibranor was generally well-tolerated with a well-documented safety profile consistent with previous trials. Full results from the pivotal Phase 3 ELATIVE® trial of elafibranor in PBC were presented as late breaking data at the AASLD congress (Boston, MA) and published in the New England Journal of Medicine in November 2023. These data were used to support submissions to regulatory authorities worldwide for elafibranor as a treatment for patients with PBC having inadequate response or intolerance to ursodeoxycholic acid, the current first-line treatment for PBC. The US Food and Drug Administration (FDA) granted Priority Review for New Drug Application (NDA) in December 2023, and the European Medicine Agency (EMA) also validated the Marketing Authorization Application (MAA) for elafibranor. A third simultaneous regulatory filing of elafibranor was validated for review by the UK Medicines and Healthcare products Regulatory Agency (MHRA). Acceptance of filings in the US and Europe triggered the first milestone payment for GENFIT, which was received in February 2024, in accordance with the Collaboration and Licensing Agreement signed with Ipsen in 2021. Acute-on-Chronic Liver Failure (ACLF): GENFIT strengthened leadership and added additional assets to its ACLF franchise In May 2023, GENFIT licensed the exclusive worldwide rights of ASK1 inhibitor SRT-015 (injectable formulation in acute liver disease) from Seal Rock Therapeutics, a Seattle, Washington (USA) based clinical stage company developing potential first-in-class and best-in-class kinase inhibitors. This was followed by another asset acquisition in July 2023, where GENFIT licensed the exclusive worldwide rights of CLM-022, a potential first-in-class inflammasome inhibitor, from Celloram. Inc., a Cleveland, Ohio (USA) based biotechnology company. GENFIT will leverage Celloram’s acquired scientific insights on this molecule to finalize Investigational New Drug (IND) enabling studies of this preclinical stage asset and secure an IND for future clinical trials. GENFIT’s ACLF franchise now includes the following five assets based on differentiated mechanisms of action leveraging complementary pathways.
Diagnostics: publications in leading scientific journals 2023 was a successful year for NIS2+® with several papers published in leading scientific journals such as the Journal of Hepatology, Journal of Hepatology Reports and Hepatology Communications, which all recognized the performance and precision of GENFIT’s diagnostic technology. ESG achievements: recognition by independent bodies Ethifinance upgraded GENFIT’s ESG performance level from bronze to gold and accorded GENFIT a two out of 75 biopharmaceutical sector ranking. Furthermore, GENFIT was classified by ODDO Research as "Best-in-Class" in its sector, based on two main criteria: activity impact and ESG maturity. GENFIT equally obtained a “Prime status” label by ISS ESG, upgrading its corporate rating from C to C+. Corporate governance updates At the Company’s Annual Shareholders’ Meeting held on May 24, 2023, all of the resolutions endorsed by the Board of Directors were adopted by a significant majority of the votes cast. This includes the renewal of financial authorizations. In June 2023, Sandra Silvestri, M.D., Ph.D., replaced Steven Hildemann M.D., Ph.D., on the Board of Directors of the Company as representative of Ipsen, the legal entity that holds the board seat. In the first half of 2023, Sakina Sayah Jeanne and Tom Huijbers joined GENFIT’s Executive Committee as Executive Vice-President Research & Translational Science and Executive Vice-President Regulatory, respectively. II. Outlook 2024 PBC: major catalyst with potential to trigger a new revenue stream Regulatory filing acceptance has been obtained in the US, Europe and the United Kingdom and a Priority Review has been granted for an NDA by the FDA for elafibranor in PBC with a PDUFA target action date of June 10, 2024. Execution of R&D roadmap In 2024, GENFIT will prioritize the execution of its clinical development programs, as well as research programs focused on pre-clinical/non-clinical development. ACLF: key milestones GENFIT will also continue its efforts to further strengthen its position as scientific leader in the field of ACLF. GENFIT’s R&D efforts have pivoted from chronic to acute liver diseases, with a strong focus on ACLF where the unmet medical need is very important and for which there are currently no approved therapies. Our therapeutic candidates have been strategically selected based on the pathophysiology of ACLF to address the most relevant pathways via differentiated and complementary modes of action.
Other life-threatening diseases franchise: key milestones GNS561 in cholangiocarcinoma (CCA) The GNS561 Phase 1b/2a clinical trial is currently ongoing and preliminary data from Phase 1b is targeted by the end of 2024. VS-01-HAC Following completion of the non-clinical feasibility study, we plan to develop formulation optimization for specific pediatric implementation and conduct IND enabling nonclinical studies with a target to complete such studies in 2024. Diagnostics franchise NIS2+®: first-ever approved drug for MASH could lead to an increased need for a non-invasive test On March 14, 2024, Madrigal Pharmaceuticals announced FDA approval of Rezdiffra™ (resmetirom) in conjunction with diet and exercise for the treatment of adults with non-cirrhotic MASH with moderate to advanced liver fibrosis. Rezdiffra™ is thus the first-ever approved drug for the treatment of MASH, which should increase the focus on diagnosis over the coming years. Our aim is to pursue our scientific publication plan, particularly focusing on the capabilities of NIS2+® as a potential tool to monitor a patient’s response to treatment, and also to move forward with the development of an IVD version of the test, either in collaboration with a commercial partner or by ourselves, in order to make NIS2+® accessible to as many patients as possible worldwide. TS-01: in development for measuring blood ammonia levels The development of TS-01, a device based on the polymersome technology, is being carried out in collaboration with ZHAW School of Engineering and intends to measure ammonia in the blood. The next steps include validation of the test in blood and further miniaturization of the device. III. Financial results (*)
(*) Audit procedures on the Consolidated Financial Statements have been substantially completed. The Report of Independent Registered Public Accounting Firm is forthcoming. Revenues and other incomes Revenue and other operating income for 2023 amounted to €38.2 million compared to €26.6 million for 2022. Revenue amounted to €28.6 million in 2023 compared to €20.2 million in 2022. Revenue for 2023 is primarily composed of the following:
Other operating income amounted to 9.6 million in 2023 compared to 6.4 million in 2022, and is primarily composed of the following:
Operating results and expenses Operating expenses for 2023 amounted to €64.8 million compared to €53.9 million for 2022. This is comprised of research and development expenses, general and administrative expenses, marketing and market access expenses, reorganization and restructuring expenses, and other operating expenses. The increase is due to multiple factors:
In 2023, GENFIT generated a consolidated operating loss of €26.6 million, compared to an operating loss of €27.3 million in 2022. Financial results 2023 resulted in a financial loss of €1.9 million compared to a financial profit of €3.5 million in 2022. Our net financial loss for 2023 consisted primarily of €0.5 million in foreign exchange gain on cash and cash equivalents, €3.2 million in interest income, offset by €4.6 million of interest expense, and €1.0 million in foreign exchange losses. Cash position As of December 31, 2023, the Company’s cash and cash equivalents amounted to €77.8 million compared with €136.0 million as of December 31, 2022. This amount does not include the receipt in February 2024 of a €13.3 million milestone payment from Ipsen, which was invoiced in December 2023, triggered by the acceptance of the NDA filing by the FDA and MAA by the EMA for accelerated approval of elafibranor in PBC in December 2023. As previously indicated in past communications2, in 2024 GENFIT expects to receive total milestone payments of approximately €89 million (including the €13.3 million milestone already received in February 2024), subject to the approval and commercialization of elafibranor in PBC. The decrease in cash and cash equivalents takes into account our continued research and development efforts, notably for:
We expect that our existing cash and cash equivalents will enable us to fund our operating expenses and capital expenditure requirements until approximately the fourth quarter of 2025. This is based on current assumptions and programs, and does not include exceptional events. This estimation includes our expectations to receive future milestone revenue in 2024, subject to approval by applicable regulatory authorities and US and European commercial launches of elafibranor in PBC, representing a total of approximately €75.2 million. Consolidated Statement of Operations*
(*) Audit procedures on the Consolidated Financial Statements have been substantially completed. The Report of Independent Registered Public Accounting Firm is forthcoming. Consolidated Statement of Financial Position* Assets
(*) Audit procedures on the Consolidated Financial Statements have been substantially completed. The Report of Independent Registered Public Accounting Firm is forthcoming. Liabilities
(*) Audit procedures on the Consolidated Financial Statements have been substantially completed. The Report of Independent Registered Public Accounting Firm is forthcoming. Statement of Cash Flows*
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