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EILEAN THERAPEUTICS ACQUIRES BEST-IN-CLASS NON-CLINICAL PTPN2 PROGRAM | ||
By: PR Newswire Association LLC. - 04 Mar 2024 | Back to overview list |
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DOVER, Del., March 4, 2024 /PRNewswire/ -- Eilean Therapeutics LLC, a biopharmaceutical company dedicated to discovering and developing best-in-class and first-in-class small molecule inhibitors to target resistance mechanisms in hematologic and solid malignancies, today announced the acquisition of Ness Therapeutics Inc (Ness) in an all-equity transaction. Ness is developing best-in-class PTPN2 inhibitors providing an immuno-oncological therapy with an improved safety and tolerability profile. Protein tyrosine phosphatase non-receptor type 2 (PTPN2), also known as T cell protein tyrosine phosphatase (TC-PTP), is ubiquitously expressed, primarily in hematopoietic and placental cells. As a critical negative regulator of the JAK-STAT pathway, PTPN2 functions to directly regulate signaling through cytokine receptors, including IFN?. Thus, enhancing IFN? sensing and signaling through the inhibition of PTPN2 is a potential therapeutic strategy to improve the efficacy of cancer immunotherapy regimens. Ness' lead molecules demonstrate sub-nanomolar PTPN2/PTPN1 inhibitory activity and outstanding > 1000-fold selectivity against all other phosphatases, exhibit high oral bioavailability and good safety. In addition, lead inhibitors induce tumor cells' susceptibility to IFN? and suppress their growth with a high efficacy. About Eilean Therapeutics Media Contact: View original content to download multimedia:https://www.prnewswire.com/news-releases/eilean-therapeutics-acquires-best-in-class-non-clinical-ptpn2-program-302076756.html SOURCE Eilean Therapeutics |
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