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Achaogen Submits Response to ASPR/BARDA Request for Information (RFI) for Antimicrobial Resistance Project BioShield | ||
By: Nasdaq / GlobeNewswire - 14 Feb 2019 | Back to overview list |
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-- Plazomicin may be well-suited to play a critical role in biodefense preparedness -- SOUTH SAN FRANCISCO, Calif., Feb. 14, 2019 (GLOBE NEWSWIRE) -- Achaogen, Inc. (NASDAQ: AKAO), a biopharmaceutical company discovering, developing and commercializing innovative antibacterial agents to address multi-drug resistant (MDR) gram-negative infections, today announced that it has responded to a Request for Information (RFI) regarding antibacterial products with the potential to treat resistant biothreat pathogens. The RFI was solicited by the Assistant Secretary for Preparedness and Response (ASPR) / the Biomedical Advanced Research and Development Authority (BARDA) under Project BioShield. The RFI specifically requested information on availabilities and capabilities for procuring, stockpiling and investing in the ongoing development of antibiotic products for commercial use for treatment of multiple biodefense indications, including pneumonic plague and tularemia, for which plazomicin has demonstrated preclinical efficacy. “We have continued to look for ways to expand our long and collaborative partnership with BARDA,” said Blake Wise, Achaogen’s Chief Executive Officer. “Project BioShield’s mission of accelerating public health preparedness is profoundly important. We believe that plazomicin is well-suited to playing a critical role in biodefense preparedness and we are hopeful that industry responses to this RFI will encourage BARDA to progress to a Request for Proposal (RFP).” Plazomicin, marketed as ZEMDRI® in the United States, was approved by the U.S. Food and Drug Administration (FDA) in June 2018 for the treatment of adults with complicated urinary tract infections, including pyelonephritis, due to certain Enterobacteriaceae. Plazomicin was developed through FDA approval with support from BARDA which provided $124.4 million in research and development funding over the lifetime of the program, starting in 2010. Plazomicin is an aminoglycoside antibiotic designed to overcome the most clinically relevant mechanisms that inactivate older members of the class, such as gentamicin. Gentamicin is a mainstay of therapy for the treatment of threat pathogens such as Yersinia pestis (e.g. pneumonic plague) and Franciscella tularensis (e.g. pneumonic tularemia). Along with anthrax, these pathogens are considered “Category A” threats by the Centers for Disease Control and Prevention, representing the highest level threat due to ease of dissemination and transmission, and high associated mortality. There is an increasing risk of having to confront resistant outbreaks of Y. pestis and F. tularensis as transmissible resistance in community and hospital pathogens increases. “Our appropriate focus on stewardship and targeted delivery of the newest drugs to address only the most resistant pathogens has created a dynamic that could severely hinder response time, by months or even years, if there is a sudden outbreak of a resistant form of a disease such as pneumonic plague,” said Dr. Ryan Cirz, Achaogen’s Vice President of Research. ”A public-private partnership to better prepare for such an event would be an exciting development.” About the Antibiotic Resistance Project BioShield About Achaogen Forward-Looking Statements Source: Achaogen, Inc © 2019 Achaogen, Inc. All Rights Reserved. CONTACT: Investor and Media Contact: Denise Powell denise@redhousecomms.com 510.703.9491 |
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Copyright 2019 Nasdaq / GlobeNewswire | Back to overview list |