|CSL Seqirus Presents Real-World Evidence at ESWI Demonstrating the Impact of Influenza Vaccination Campaigns to Help Protect People and Healthcare Systems|
|By: PR Newswire Association LLC. - 19 Sep 2023||Back to overview list
SUMMIT, N.J., Sept. 18, 2023 /PRNewswire/ -- CSL Seqirus, a business of CSL (ASX:CSL), today shared new real-world evidence (RWE) studies conducted in the United States, demonstrating the value of influenza vaccination in protecting public health. These data are being presented at oral and poster sessions at the European Scientific Working Group on Influenza (ESWI) Conference taking place in Valencia, from September 17-20, 2023.
One study evaluating the clinical impact of seasonal influenza in adults from 2015 to 2020, revealed a notable rise in pneumonia-related medical encounters with increasing age following an influenza encounter.1 On average about one third of adult patients above 50 years of age who were hospitalized for influenza were diagnosed with pneumonia during their hospitalization.1
"This finding may be explained by our immune systems beginning to wane as we age, increasing the risk of developing serious flu-related complications," said Dr. Gregg Sylvester, Chief Health Officer at CSL Seqirus. "It is important to conduct real world studies to evaluate influenza vaccine effectiveness, gathering insights to tailor our ongoing approach to preventing disease and serious flu-related illness, particularly among these vulnerable populations."
Results from a separate retrospective cohort study during the 2019/20 influenza season demonstrate the clinical benefit of an adjuvanted inactivated trivalent influenza vaccine compared with high-dose inactivated trivalent influenza vaccine in preventing influenza-related medical encounters (IRMEs), outpatient IRMEs, and influenza- or pneumonia-related hospitalizations among adults with cumulative risk factors.2 Results also found comparable effectiveness of these influenza vaccines in individuals with no high-risk conditions.2
In a third study, data from a retrospective test-negative design showed the clinical value of cell-based quadrivalent influenza vaccines (QIVc) compared with traditional egg-based quadrivalent influenza vaccines (QIVe) in preventing outpatient test-confirmed influenza.3 The study was conducted over three consecutive influenza seasons characterized by different circulating influenza viruses and degrees of egg-adaptation and align with previously published QIVc relative effectiveness studies for the same seasons.3 Review of three seasons of real-world data allows for evaluation of trends in the effectiveness of QIVc over time and in the context of season-over-season changes, given the variability of the virus.3
"Vaccines remain one of our greatest tools for fighting influenza, a disease that continues to result in substantial morbidity and mortality worldwide," said Raja Rajaram, Head of Global Medical Strategy, CSL Seqirus. "At CSL Seqirus, we are committed to advancing the science of influenza prevention, and these studies show the benefits of innovative vaccine technologies, including cell-based and adjuvanted influenza vaccine technology, on reducing the burden of flu."
RWE is a complement to randomized controlled trial (RCT) research, assessing influenza vaccine effectiveness on a continual basis and providing an ever-growing data set on real-world outcomes.
ABOUT THE STUDIES PRESENTED AT ESWI
Healthcare Resource Use and Complications Among Adults with an Influenza-Related Medical Encounter: 2015-2020 Influenza Seasons in the United Sates (V118_61RWE)
Results from the study, which included between 887,260 and 3,628,168 patients per season, found that the proportion of patients with a pneumonia-related medical encounter within 2 weeks of an index influenza-related outpatient (OP) or emergency-room (ER) visit increased with age.1
Following an outpatient influenza visit, the mean percentage of pneumonia-related medical encounters was 2.1% for patients 18-49, 3.9% for 50-64, and 6.9% for 65+.1 Following an emergency-room visit, the mean percentage was 4.7% for patients 18-49; 9.0% for 50-64; 14.9% for 65+.1 Compared to other age groups, pneumonia diagnoses among hospitalized influenza patients were most common among patients 50–64 (35.7%).1
Relative Effectiveness of the MF59-Adjuvanted Influenza Vaccine vs High-Dose Influenza Vaccine in Older Adults with Influenza Risk Factors during the 2019-2020 U.S. Influenza Season
Superior Effectiveness of Cell-Based Versus Egg-Based Quadrivalent Influenza Vaccines Against Outpatient Test-Confirmed Influenza Over Three Consecutive Seasons in the United States
The analysis found that QIVc showed a clinical benefit compared to QIVe in prevention of test-confirmed influenza in the outpatient care setting, with estimated relative vaccine effectiveness (rVEs) (95% CI) of 14.8% (7.0 – 22.0) in 2017–-18, 12.5% (4.7 – 19.6) in 2018-–19 and 10.0% (2.7 – 16.7) in 2019–-20.3 Results of sensitivity analyses supported the robustness of the main analyses.3 The analysis highlighted the clinical value of QIVc compared with QIVe in preventing outpatient test-confirmed influenza over three seasons characterized by different circulating strains and degrees of egg adaptation.3 Estimated rVEs were consistent with previously published studies using influenza-like illness and lab-confirmed outcome.3
About Seasonal Influenza
About CSL Seqirus
For more information about CSL Seqirus, visit CSLSeqirus.com.
FLUCELVAX® QUADRIVALENT (Influenza Vaccine)
What is FLUCELVAX® QUADRIVALENT (Influenza Vaccine)?
Who should not get FLUCELVAX QUADRIVALENT?
Before receiving FLUCELVAX QUADRIVALENT, tell your healthcare provider about all medical conditions, including if you:
What are the most common side effects of FLUCELVAX QUADRIVALENT?
Additional side effects seen in children include:
These are not all of the possible side effects of FLUCELVAX QUADRIVALENT. You can ask your healthcare provider for more information and for advice about any side effects that concern you.
To report SUSPECTED ADVERSE REACTIONS, contact CSL Seqirus at 1-855-358-8966 or VAERS at 1-800-822-7967 or www.vaers.hhs.gov.
Before receiving this vaccine, please see the full US Prescribing Information for FLUCELVAX QUADRIVALENT. The information provided here does not include all that is known about FLUCELVAX QUADRIVALENT. To learn more, talk with your healthcare provider or pharmacist.
FLUCELVAX® QUADRIVALENT is a registered trademark of CSL Seqirus UK Limited or its affiliates.
1 McGovern I et al. Healthcare Resource Use and Complications Among Adults with an Influenza-Related Medical Encounter: 2015-2020 Influenza Seasons in the United States. Presented at ESWI 2023.
2 Imran M et al. Relative Effectiveness of the MF59-Adjuvanted Influenza Vaccine vs High-Dose Influenza Vaccine in Older Adults with Influenza Risk Factors during the 2019-2020 U.S. Influenza Season. Presented at ESWI 2023.
3 Stein AN et al. Superior Effectiveness of Cell-Based Versus Egg-Based Quadrivalent Influenza Vaccines Against Outpatient Test-Confirmed Influenza Over Three Consecutive Seasons in the United States. Presented at ESWI 2023.
4 Centers for Disease Control and Prevention (CDC). (2022). Key Facts about Influenza. Retrieved from?https://www.cdc.gov/flu/about/keyfacts.htm. Accessed?August 2023.
5 CDC. (2023). 2022-2023 Preliminary In-Season Burden Estimate. Retrieved from: https://www.cdc.gov/flu/about/burden/preliminary-in-season-estimates.htm. Accessed August 2023.
6 CDC. (2023). Who Needs a Flu Vaccine and When. Retrieved from: https://www.cdc.gov/flu/prevent/vaccinations.htm. Accessed August 2023.
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