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Dapagliflozin is Well Tolerated in Hospitalized COVID-19 Patients | ||
By: PR Newswire Association LLC. - 27 Jun 2021 | Back to overview list |
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WASHINGTON, June 27, 2021 /PRNewswire/ -- DARE-19 is the first large randomized clinical trial to assess sodium-glucose cotransporter-2 (SGLT2) inhibitors in patients with and without type 2 diabetes hospitalized with COVID-19. Additional findings from the trial were presented today at the virtual 81st Scientific Sessions of the American Diabetes Association® (ADA). Patients with cardiometabolic risk factors, including type 2 diabetes, are at higher risk for developing serious COVID-19 related complications such as organ failure and death. In fact, Americans with diabetes and other related underlying health conditions are hospitalized six times more often and are 12 times more likely to die of COVID-19 than those without. Previous studies have shown SGLT2 inhibitors, a medication class initially used to help lower blood glucose, provide organ protection in patients with type 2 diabetes, heart failure, and chronic kidney disease. DARE-19, an investigator-sponsored, international, randomized trial, compared SGLT2 inhibitor dapagliflozin to placebo in 1,250 patients hospitalized for COVID-19 who also had a history of hypertension, atherosclerotic cardiovascular disease, heart failure with either preserved or reduced ejection fraction, type 2 diabetes, or stage three to four chronic kidney disease with estimated glomerular filtration rate (eGFR) between 25 and 60. Patients were recruited across 95 centers in seven countries between April 2020 and January 2021. Approximately half of the patients had a history of type 2 diabetes. Patients received dapagliflozin or placebo for 30 days in addition to the standard of care for COVID-19 in the participating hospital. Results of the trial indicated:
"Previously, there were some concerns with using SGLT2 inhibitors in COVID-19 patients due to the potential risk for acute kidney injury and diabetic ketoacidosis. However, our results show dapagliflozin is well tolerated, with no new safety concerns," said Mikhail Kosiborod, Cardiologist and Vice President for Research at Saint Luke's Health System, Professor of Medicine, University of Missouri-Kansas City and lead investigator of the study. "We believe that our findings do not support routine discontinuation of SGLT2 inhibitors in patients hospitalized with COVID-19 that have other indications for these agents (such as Type 2 diabetes, heart failure and CKD), as long as patients are monitored." The authors state that future trials are needed to further evaluate possible effects of dapagliflozin on the risk of organ failure or death in patients hospitalized with COVID-19. They also note DARE-19, which was funded by AstraZeneca, has important implications for future research, as it raises a hypothesis that SGLT2 inhibitors may offer organ protection in other types of acute illness such as sepsis, which should be explored in future studies. Research presentation details: Dr. Kosiborod and study investigators presented the findings of the trial during the symposium listed below:
For more information or to request an interview with Dr. Kosiborod, please contact the ADA Scientific Sessions media team at SciSessionsPress@diabetes.org. About the ADA's Scientific Sessions About the American Diabetes Association Contact: Daisy Diaz, 703-253-4807 View original content to download multimedia:https://www.prnewswire.com/news-releases/dapagliflozin-is-well-tolerated-in-hospitalized-covid-19-patients-301320642.html SOURCE American Diabetes Association |
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Copyright 2021 PR Newswire Association LLC. | Back to overview list |